Antiulcer and gastric antisecretory agent (proton pump inhibitor)
Indications
Gastro-oesophageal reflux
Gastric and duodenal ulcers in adult
Forms and strengths
10 mgdispersible gastro-resistant tablet
20 mg gastro-resistant capsule
Dosage
Gastro-oesophageal reflux
Child under 5 kg: 0.7 to 1.4 mg/kg (max. 2.8 mg/kg daily) once daily in the morning
Child 5 to 10 kg: 5 mg once daily in the morning
Child 10 to 20 kg: 10 mg once daily in the morning
Child over 20 kg and adult: 20 mg once daily in the morning
Age
Weight
1 mg/ml sol.(a)
10 mg tablet(b)
20 mg capsule
< 2 months
< 5 kg
3 ml
–
–
2 months to < 1 year
5to < 10 kg
5 ml
–
–
1 to < 6 years
10to < 20 kg
–
1tab
–
≥ 6 years and adult
≥ 20 kg
–
–
1 cap
In a syringe,dissolve one 10 mg dispersible tablet in 10 ml of water to obtain a solution of 1 mg/ml.
Dissolve 1 dispersible tablet in half a glass of water.
Gastric and duodenal ulcers
Adult: 20 mg once daily in the morning
In severe or recurrent cases, dose can be increased if necessary to 40 mg once daily.
Duration
Gastro-oesophageal reflux: 3 days (short-term relief of symptoms) or 4 to 8 weeks(long-term treatment)
Gastric and duodenal ulcers:7 to 10 days or up to 8 weeks (severe or recurrent cases)
Contra-indications, adverse effects, precautions
Do not exceed 0.7 mg/kg daily (max. 20 mg daily) in patients with severe hepatic impairment. May cause: headache, diarrhoea, constipation, nausea, vomiting,abdominal pain, dizziness, skin rash, fatigue.
Monitor combination with:
atazanavir, itraconazole (decreased efficacy of these drugs);
diazepam, phenytoin, digoxin, raltegravir (increased toxicity of these drugs).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication
Remarks
Do not open capsules.
Omeprazole is also used in combination with 2 antibacterial drugs for cure of Helicobacter pylori infection, at a dosage of 20 mg 2 times daily for 7 days.
Storage
– Below 25 °C
Once dissolved, dispersible tablets should be administered within 30 minutes.