Atazanavir

Generic Name: Atazanavir

Brand Names:

Availability: Available with Prescription

Therapeutic action

Child 10 to < 25 kg: one 200 mg capsule once daily (+ 100 mg ritonavir once daily)
Child≥ 25 kg and adult: one 300 mg/100 mg tablet once daily

Depending on the efﬁciency and tolerance of atazanavir and ritonavir.

Do not administer to patients with severe hepatic impairment.
Administer with caution and monitor use in patients with haemophilia (increased bleeding) or mild to moderate hepatic impairment.
May cause:
- jaundice, gastrointestinal disturbances, headache, insomnia, fatigue, peripheral neuropathy, asymptomatic hyperbilirubinaemia, cholelithiasis, urolithiasis, conduction disorders, hyperglycaemia, hyperlipidaemia, lipodystrophy;
- skin rash sometimes severe, hepatic disorders; in this event, stop treatment immediately.
Do not combine with rifampicin or omeprazole (decreased plasma concentrations of atazanavir):
- replace rifampicin with rifabutin;
- if omeprazole is necessary, do not exceed 20 mg daily and take each drug 12 hours apart.
Administer with caution and monitor combination with drugs that prolong the QT interval (amiodarone, co-artemether, meﬂoquine, quinine, haloperidol, etc.).
Do not administer simultaneously with antacids containing aluminium or magnesium hydroxide. Take 2 hours apart.
Atazanavir in combination with ritonavir reduces the efﬁciency of implants and oral contraceptives: use injectable medroxyprogesterone or an intrauterine device or an oral contraceptive containing at least 30 micrograms of ethinylestradiol per tablet.
Pregnancy: no contra-indication; monitor bilirubin levels and/or signs of jaundice in neonates.

Take with meals together with ritonavir. Do not open the capsules.

Also comes in 100 mg, 150 mg and 300 mg capsules, not in combination with ritonavir.

– Below 25 °C